Why polyps regenerate and we don't: towards a cellular and molecular framework for Hydra regeneration

Bosch, T. C. G. (2007) Why polyps regenerate and we don't: towards a cellular and molecular framework for Hydra regeneration Developmental biology, 303 (2). pp. 421-433. DOI 10.1016/j.ydbio.2006.12.012.

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Abstract

The basis for Hydra's enormous regeneration capacity is the “stem cellness” of its epithelium which continuously undergoes self-renewing mitotic divisions and also has the option to follow differentiation pathways. Now, emerging molecular tools have shed light on the molecular processes controlling these pathways. In this review I discuss how the modular tissue architecture may allow continuous replacement of cells in Hydra. I also describe the discovery and regulation of factors controlling the transition from self-renewing epithelial stem cells to differentiated cells.

Document Type: Article
Keywords: Regeneration; Stem cells; Epithelium; Peptides; Cnidaria; Hydra
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.1016/j.ydbio.2006.12.012
ISSN: 0012-1606
Projects: Future Ocean
Date Deposited: 18 Apr 2011 12:44
Last Modified: 27 Jan 2012 05:40
URI: http://eprints.uni-kiel.de/id/eprint/11061

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